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Applied-genomics PDF Print E-mail
Applied-genomics

The goal of Applied Genomics is to develop a novel set of tools useful for the detection and classification of human cancer.  We are accomplishing this by developing a process  whereby complex gene expression data is used to nominate antibodies for production and direct the analysis of the protein distribution across thousands of tumor tissues.  AGI is thereby able to identify antibodies that can act as biomarkers which define a much more sophisticated and detailed classification of cancer than is currently available.

Applied Genomics initially began from a collaboration between Stanford and Research Genetics located in Huntsville, AL (now a subsidiary of Invitrogen, Inc.). AGI was founded in 2000 by Robert Seitz, CEO of AGI and previous founder and Director of the Antibody Department at Research Genetics, and Doug Ross, MD, PhD, Chief Scientific Officer of AGI and former postdoctoral fellow in Patrick Brown's laboratory at Stanford University.

The company has two facilities: corporate headquarters in Huntsville, AL where the antibodies are produced and a research facility in Sunnyvale, CA.

AGI is developing a novel set of tools and the expertise for the detection and classification of human cancer.  We create and validate antibodies targeted to candidates selected from gene expression data and assess their clinical relevance for diagnostic and therapeutic antibody products.

The products based on these tools and experience are:

Customized proteomics information for our pharmaceutical partners
Using our own or a partners' tissue repository we assess protein expression via tissue arrays, rapidly building a proteomics database that meets the specific demands of our partners' projects

.Diagnostic panels of antibodies useful for identifying clinically relevant subcategories of tumors. 
These panels are useful to companies conducting clinical trials in order to divide clinical trial patient populations into clinical subcategories to obtain optimal knowledge or prediction of drug efficacy.

 Therapeutic drug development candidates. 
Having identified novel tumor classes, new therapeutics can be developed that specifically target these patient groups.

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